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Slay the Spire 2‘s early access build has over 250 relics to find on a run, and all of them have unique in-game effects.

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Some relics are limited to use with specific characters. However, many of them can be used with all characters. Let’s quickly look at all the relics and their in-game effects, so you have a clear idea about which ones to draft on priority.

All relics and effects in Slay the Spire 2

The tables below have all the relics that you can find in the current build. I have separated the tables as per their rarities.

Common

RelicsHow it works
Amethyst AubergineEnemies drop 10 additional Gold
AnchorStart each combat with 10 Block
Bag of PreparationAt the start of each combat, draw 2 additional cards
Blood VialAt the start of each combat, heal 2 HP
Bone FluteWhenever Osty attacks, gain 2 Block.
Book of Five RingsEvery 5 cards you add to your Deck, heal 15 HP.
Bronze ScalesStart each combat with 3 Thorns.
Centennial PuzzleThe first time you lose HP each combat, draw 3 cards.
Data DiskStart each combat with 1 Focus.
Fencing ManualAt the start of each combat, Forge 10.
Festive PopperAt the start of each combat, deal 9 damage to ALL enemies.
GorgetAt the start of each combat, gain 4 Plating.
Happy FlowerEvery 3 turns, gain Colorless Energy.
Juzu BraceletRegular enemy combats are no longer encountered in ? rooms.
LanternStart each combat with an additional Colorless Energy.
Meal TicketWhenever you enter a shop room, heal 15 HP.
Oddly Smooth StoneStart each combat with 1 Dexterity.
PendulumWhenever you shuffle your Draw Pile, draw a card.
PermafrostThe first time you play a Power each combat, gain 6 Block.
Potion BeltUpon pickup, gain 2 potion slots.
Red SkullWhile your HP is at or below 50%, you have 3 additional Strength.
Regal PillowWhenever you Rest, heal an additional 15 HP.
Snecko SkullWhenever you apply Poison, apply an additional 1 Poison.
StrawberryUpon pickup, raise your Max HP by 7.
Strike DummyCards containing “Strike” deal 3 additional damage.
Tiny MailboxWhenever you Rest, procure a random potion.
VajraStart each combat with 1 Strength.
Venerable Tea SetWhenever you enter a Rest Site, start the next combat with an additional 2 Colorless Energy.
War PaintUpon pickup, Upgrade 2 random Skills.
WhetstoneUpon pickup, Upgrade 2 random Attacks.

Uncommon

RelicsHow it works
AkebekoAt the start of each combat, gain 8 Vigor.
Bag of MarblesAt the start of each combat, apply 1 Vulnerable to ALL enemies.
BellowsThe first Hand you draw each combat is Upgraded.
Book Repair KnifeWhenever a non-Minion enemy dies to Doom, heal 3 HP.
Bowler HatGain 20% additional Gold.
CandelabraAt the start of your 2nd turn, gain 2 Colorless Energy.
Eternal FeatherFor every 5 cards in your Deck, heal 3 HP whenever you enter a Rest Site.
Funerary MaskAt the start of each combat, add 3 Souls into your Draw Pile.
Galactic DustFor every Star spent, gain 10 Block.
Gold-Plated CandlesYour rightmost Orb triggers its passive an additional time.
Gremlin HornWhenever an enemy dies, gain Colorless Energy and draw 1 card.
Horn CleatAt the start of your 2nd turn, gain 14 Block.
Joss PaperEvery 5 times you Exhaust a card, draw 1 card.
KusarigamaEvery time you play 3 Attacks in a single turn, deal 6 damage to a random enemy.
Letter OpenerEvery time you play 3 Skills in a single turn, deal 5 damage to ALL enemies.
Lucky FyshWhenever you add a card to your Deck, gain 15 Gold.
Mercury HourglassAt the start of your turn, deal 3 damage to ALL enemies.
Miniature CannonUpgraded Attacks deal 3 additional damage.
NunchakuEvery time you play 10 Attacks, gain Colorless Energy.
OrichalcumIf you end your turn without Block, gain 6 Block.
Ornamental FanEvery time you play 3 Attacks in a single turn, gain 4 Block.
PantographAt the start of each Boss combat, heal 25 HP.
Paper PhrogEnemies with Vulnerable take 75% more damage rather than 50%.
Parrying ShieldIf you end a turn with at least 10 Block, deal 6 damage to a random enemy.
PearUpon pickup, raise your Max HP by 10.
Pen NibEvery 10th Attack you play deals double damage.
Petrified ToadAt the start of each combat, procure a Potion-Shaped Rock.
PlanisphereWhenever you enter a ? room, heal 4 HP.
Red MaskAt the start of each combat, apply 1 Weak to ALL enemies.
RegaliteWhenever you create a Colorless card, gain 2 Block.
Reptile TrinketWhenever you use a potion, gain 3 Strength this turn.
Ripple BasinIf you did not play any Attacks during your turn, gain 4 Block.
Self-Forming ClayWhenever you lose HP in combat, gain 3 Block next turn.
Sparkling RougeAt the start of your 3rd turn, gain 1 Strength and 1 Dexterity.
Stone CrackerAt the start of Boss combats, Upgrade 3 random cards in your Draw Pile for the rest of combat.
Symbiotic VirusAt the start of each combat, Channel 1 Dark.
TingshaWhenever you discard a card during your turn, deal damage to a random enemy for each card discarded.
Tuning ForkEvery time you play 10 Skills, gain 7 Block.
Twisted FunnelAt the start of each combat, apply 4 Poison to ALL enemies.
VambranceThe first time you gain Block from a card each combat, double the amount gained.

Rare

RelicHow it works
Art of WarIf you do not play any Attacks during your turn, gain an additional Colorless Energy next turn.
Beating RemnantYou cannot lose more than 20 HP in a single turn.
Big HatAt the start of each combat, add 2 random Ethereal cards into your Hand.
BookmarkAt the end of each turn, lower the cost of a random Retained card by 1 until played.
Captain’s WheelAt the start of your 3rd turn, gain 18 Block.
ChandelierAt the start of your 3rd turn, gain 3 Colorless Energy.
Charon’s AshesWhenever you Exhaust a card, deal damage to ALL enemies.
Cloak ClaspAt the end of your turn, gain 1 Block for each card in your Hand.
Demon TongueThe first time you lose HP on your turn, heal HP equal to the amount lost.
Emotion ChipIf you lost HP during the previous turn, trigger the passive ability of all Orbs at the start of your turn.
Frozen EggWhenever you add a Power into your Deck, Upgrade it.
Gambling ChipAt the start of each combat, discard any number of cards, then draw that many.
Game PieceWhenever you play a Power, draw 1 card.
GiryaYou can now gain Strength at Rest Sites.
Helical DartWhenever you play a Shiv, gain 1 Dexterity this turn.
Ice CreamEnergy is now conserved between turns.
Intimidating HelmetWhenever you play a card that costs 1 Colorless Energy or more, gain 4 Block.
Ivory TileWhenever you play a card that costs 3 Colorless Energy or more, gain 1 Colorless Energy.
KunaiEvery time you play 3 Attacks in a single turn, gain 1 Dexterity.
Lasting CandyEvery other combat, your card rewards gain an additional Power.
Lizard TailWhen you would die, heal to 50% of your Max HP instead.
Lunar PastryAt the end of your turn, gain Star.
MangoUpon pickup, raise your Max HP by 14.
Meat on the BoneIf your HP is at or below 50% at the end of combat, heal 12 HP.
MetronomeThe first time you Channel 7 Orbs each combat, deal damage to ALL enemies.
Mini RegentThe first time you spend Star each turn, gain 1 Strength.
Molten EggWhenever you add an Attack card to your Deck, Upgrade it.
Mummified HandWhenever you play a Power, a random card in your Hand is free to play that turn.
Old CoinUpon pickup, gain 300 Gold.
Orange DoughAt the start of each combat, add 2 random Colorless cards into your Hand.
Paper KraneEnemies with Weak deal 40% less damage to you rather than 25%.
PocketwatchWhenever you play 3 or fewer cards during your turn, draw 3 additional cards at the start of your next turn.
Power CellAt the start of each combat, add 2 zero-cost cards from your Draw Pile into your Hand.
Prayer WheelNormal enemies drop an additional card reward.
Rainbow RingThe first time you play an Attack, Skill, and Power each turn, gain 1 Strength and 1 Dexterity.
Razor ToothEvery time you play an Attack or Skill, Upgrade it for the remainder of combat.
Ruined HelmetThe first time you gain Strength each combat, double the amount gained.
ShovelYou can now dig at Rest Sites to obtain a random Relic.
ShurikenEvery time you play 3 Attacks in a single turn, gain 1 Strength.
Stone CalendarAt the end of turn 7, deal 52 damage to ALL enemies.
Sturdy ClampUp to 10 Block persists across turns.
The CourierThe merchant no longer runs out of cards, relics, or potions, and his prices are reduced by 20%.
Tough BandagesWhenever you discard a card during your turn, gain 3 Block.
Toxic EggWhenever you add a Skill into your Deck, Upgrade it.
Tungsten RodWhenever you would lose HP, lose 1 less.
Unceasing TopWhenever you have no cards in Hand during your turn, draw a card.
Unsettling LampEach combat, the first time you play a card that Debuffs an enemy, double its effect.
Vexing PuzzleboxAt the start of each combat, add a random card into your Hand. It costs 0 Colorless Energy.
White Beast StaturePotions always appear in combat rewards.
White StarElites drop an additional Rare card reward.

Shop

RelicHow it works
Belt BuckleWhile you have no potions, you have 2 additional Dexterity.
BreadAt the start of your first turn, lose 2 Colorless Energy. At the start of all other turns, gain Colorless Energy.
BrimstoneAt the start of your turn, gain 2 Strength and ALL enemies gain 1 Strength.
Burning SticksThe first time each combat you Exhaust a Skill, add a copy of it to your Hand.
CauldronUpon pickup, brews 5 random potions.
Chemical XThe effects of your cost X cards are increased by 2.
Dingy RugCard rewards can now contain Colorless cards.
Dolly’s MirrorUpon pickup, obtain an additional copy of a card in your Deck.
Dragon FruitWhenever you gain Gold, raise your Max HP by 1.
Ghost SeedStrikes and Defends gain Ethereal.
Gnarled HammerUpon pickup, Enchant up to 3 Attacks with Sharp 3.
KifudaUpon pickup, Enchant up to 3 cards with Adroit.
Lava LampAt the end of combat, Upgrade all card rewards if you took no damage.
Lee’s WaffleUpon pickup, raise your Max HP by 7 and heal all of your HP.
Membership Card50% discount on all products!
Miniature TentYou may choose any number of options at Rest Sites.
Mystic LighterEnchanted Attacks deal 9 additional damage.
Ninja ScrollAt the start of each combat, add 3 Shivs into your Hand.
OrreryUpon pickup, gain 5 card rewards.
Punch DaggerUpon pickup, Enchant an Attack with Momentum 5.
Ringing TriangleRetain your Hand on the first turn of combat.
Royal StampUpon pickup, choose an Attack or Skill in your Deck to Enchant with Royally Approved.
Runic CapacitorIf you end your turn with no cards in your Hand, deal 20 damage to ALL enemies.
Screaming FlagonIf you end your turn with no cards in your Hand, deal 20 damage to ALL enemies.
Sling of CourageStart each Elite combat with 2 Strength.
The AbacusWhenever you shuffle your Draw Pile, gain 6 Block.
ToolboxAt the start of each combat, choose 1 of 3 random Colorless cards and add the chosen card into your Hand.
Undying SigilEnemies with at least as much Doom as HP deal 50% less damage.
Vitruvian MinionCards containing “Minion” deal double damage and gain double Block.
Wing CharmA random card in each card reward is Enchanted with Swift 1.

Ancient

RelicHow it works
Alchemical CofferUpon pickup, gain 4 potion slots filled with random potions.
Arcane ScrollUpon pickup, obtain a random Rare Card to add to your Deck.
Archaic ToothUpon pickup, Transform a starter card with an ancient version.
AstrolabeUpon pickup, Transform 3 cards, then Upgrade them.
Beautiful BraceletUpon pickup, choose 3 cards in your Deck. Enchant them with Swift 3.
Biiig HugUpon pickup, remove 4 cards from your Deck. Whenever you shuffle your Draw Pile, add a Soot into your Draw Pile.
Black StarElites drop an additional Relic when defeated.
Blessed AntlerGain Colorless Energy at the start of each turn. At the start of each combat, shuffle 3 Dazed into your Draw Pile.
Blood-Soaked RoseUpon pickup, add 1 Enthralled to your Deck. Gain Colorless Energy at the start of each turn.
Booming ConchAt the start of Elite combats, draw 2 additional cards.
Brilliant ScarfThe 5th card you play each turn is free.
Calling BellUpon pickup, obtain a unique Curse and 3 Relics.
Choices Paradox At the start of each combat, add 1 of 5 random cards into your Hand. Add Retain to the chosen card.
ClawsUpon pickup, Transform up to 6 cards into Maul.
CrossbowAt the start of your turn, add a random Attack into your Hand. It costs 0Colorless Energy this turn.
Cursed PearlUpon pickup, receive Greed. Gain 333 Gold.
Delicate FrondAt the start of each combat, fill all empty potion slots with random potions.
Diamond DiademWhenever you play 2 or fewer cards in a turn, take half damage from enemies.
Distinguished CapeUpon pickup, lose 9 Max HP. Add 3 Apparitions to your Deck.
DriftwoodYou may reroll each card reward once.
Dusty TomeUpon pickup, obtain an Ancient Card.
EctoplasmYou can no longer gain Gold. Gain Colorless Energy at the start of each turn.
Electric ShrympUpon pickup, Enchant a Skill with Imbued.
Empty CageUpon pickup, remove 2 cards from your Deck.
FiddleAt the start of each turn, draw 2 additional cards. You may not draw cards during your turn.
Fur CoatUpon pickup, mark 7 random combats. Enemies in those rooms have 1 HP.
Glass EyeUpon pickup, obtain 2 Common cards, 2 Uncommon cards, and 1 Rare card.
GlitterEnchant all card rewards with Glam.
Golden CompassUpon pickup, replace the Act 2 Map with a single special path.
Golden PearlUpon pickup, gain 150 Gold.
Iron ClubEvery 4 cards you play, draw 1 card.
Jeweled MaskAt the start of combat put a random Power from your Draw Pile into your Hand, it’s free to play.
Jewelry BoxUpon pickup, add 1 Apotheosis to your Deck.
Large CapsuleUpon pickup, obtain 2 random Relics. Add an additional Strike and Defend to your Deck.
Lava RockThe Act 1 Boss drops 2 Relics.
Lead PaperweightUpon pickup, choose 1 of 2 Colorless cards to add to your Deck.
Leafy PoulticeUpon pickup, Transform 1 of your Strikes and 1 of your Defends and lose 10 Max HP.
Looming FruitUpon pickup, raise your Max HP by 31.
Lord’s ParasolWhen you encounter the Merchant, immediately obtain EVERYTHING he sells.
Lost CofferUpon pickup, gain 1 card reward and procure 1 random potion.
Massive ScrollUpon pickup, choose 1 of 3 Multiplayer Colorless Cards to add to your Deck.
Meat CleaverYou may Cook at Rest Sites.
Music BoxCreate an Ethereal copy of the first Attack you play each turn.
Neow’s TormentUpon pickup, add 1 Neow’s Fury to your Deck.
New LeafUpon pickup, Transform 1 card.
Nutritious OysterUpon pickup, raise your Max HP by 11.
Nutritious SoupUpon pickup, Enchant all Strikes in your Deck with Tezcatara’s Ember.
Pael’s BloodAt the start of your turn, draw 1 additional card.
Pael’s ClawUpon pickup, Enchant all Defends with Goopy.
Pael’s EyeThe first time each combat you end your turn without playing cards, Exhaust your Hand, and take an extra turn.
Pael’s FleshGain an additional Colorless Energy at the start of your 3rd turn, and every turn after that.
Pael’s GrowthUpon pickup, Enchant a card with Clone.
Pael’s HornUpon pickup, add 2 Relax to your Deck.
Pael’s LegionDoubles Block gained from a card, then goes to sleep for 2 turns.
Pael’s TearsIf you end your turn with unspent Colorless Energy, gain an additional Colorless Energy next turn.
Pael’s ToothUpon pickup, remove 5 cards from your Deck. After each combat, randomly add 1 back Upgraded.
Pael’s WingYou may sacrifice card rewards to Pael. Every 2 sacrifices, obtain a Relic.
Pandora’s BoxTransform ALL Strikes and Defends.
Philosopher’s StoneGain Colorless Energy at the start of each turn. ALL enemies start combat with 1 Strength.
PomanderUpon pickup, Upgrade a card.
Precarious ShearsUpon pickup, remove 2 cards from your Deck and take 13 damage.
Precise ScissorsUpon pickup, remove 1 card from your Deck.
Preserved FogUpon pickup, remove 5 cards from your Deck. Add Folly to your Deck.
Prismatic GemGain Colorless Energy at the start of each turn. Card rewards now contain cards from other colors.
Pumpkin CandleGain Colorless Energy at the start of each turn. Extinguishes at the start of Act 3.
Radiant PearlAt the start of each combat, add 1 Luminesce into your Hand.
Runic PyramidAt the end of your turn, you no longer discard your Hand.
SaiAt the start of your turn, gain 7 Block.
Sand CastleUpon pickup, Upgrade 6 random cards.
Scroll BoxesUpon pickup, lose all Gold and choose 1 of 2 packs of cards to add to your Deck.
Sea GlassSee 15 cards from another character. Choose any number of them to add to your Deck.
Seal of GoldAt the start of your turn, spend 5 Gold to gain Colorless Energy.
Sere TalonUpon pickup, add 2 random Curses and 3 Wishes to your Deck.
Signet RingUpon pickup, gain 999 Gold.
Silver CrucibleThe first 3 card rewards you see are Upgraded. The first Treasure Chest you open is empty.
Small CapsuleUpon pickup, obtain a random Relic.
Snecko EyeAt the start of your turn, draw 2 additional cards. Start each combat Confused.
SozuGain Colorless Energy at the start of each turn. You can no longer obtain potions.
Spiked GauntletsGain Colorless Energy at the start of each turn. Powers cost 1 more Colorless Energy.
Stone HumidifierWhenever you Rest at a Rest Site, raise your Max HP by 5.
StorybookUpon pickup, add 1 Brightest Flame to your Deck.
Tanx’s WhistleUpon pickup, add 1 Whistle to your Deck.
Throwing AxeThe first card you play each combat is played an extra time.
Toasty MittensAt the start of your turn, Exhaust the top card of your Draw Pile and gain 1 Strength.
Touch of OrobasUpon pickup, replace your starter Relic with an Ancient version.
Toy BoxUpon pickup, obtain 4 Wax Relics. Every 3 combats, your left-most Wax Relic will melt away.
Tri-BoomerangChoose 3 Attacks in your Deck. Enchant them with Instinct.
Velvet ChokerGain Colorless Energy at the start of each turn. You cannot play more than 6 cards per turn.
Very Hot CocoaStart each combat with an additional 4 Colorless Energy.
War HammerWhenever you kill an Elite, Upgrade 4 random cards.
Whispering EarringGain Colorless Energy at the start of each turn. Vakuu plays your first turn for you.
Yummy CookieUpon pickup, Upgrade 4 cards.

Event

RelicHow it works
Big MushroomUpon pickup, raise your Max HP by 20. At the start of each combat, draw 2 fewer cards.
Bing BongWhenever you add a card to your Deck, add one additional copy.
Bone TeaAt the start of the next combat, Upgrade your starting hand.
BrydpipUpon pickup, gain the card Byrd Swoop. A Byrdpip will accompany you in battles.
The Chosen CheeseAt the end of combat, gain 1 Max HP.
Darkstone PeriaptWhenever you obtain a Curse, raise your Max HP by 6.
Daughter of the WindWhenever you play an Attack, gain 1 Block.
Dream CatcherWhenever you Rest, you may add a card to your Deck.
Ember TeaAt the start of the next 5 combats, gain 2 Strength.
AnchorStart each combat with 4 Block.
Blood VialAt the start of each combat, heal 1 HP.
Happy FlowerEvery 5 turns, gain Colorless Energy.
Lee’s WaffleUpon pickup, heal 10% of your HP.
MangoUpon pickup, raise your Max HP by 3.
The Merchant’s RugPoor imitation. Does nothing.
OrichalcumIf you end your turn without Block, gain 3 Block.
Snecko EyeStart each combat Confused.
Strike DummyCards containing “Strike” deal 1 additional damage.
Venerable Tea SetWhenever you enter a Rest Site, start the next combat with an additional Colorless Energy.
Forgotten SoulWhenever you Exhaust a card, deal 1 damage to a random enemy.
Fragrant MushroomUpon pickup, lose 15 HP and Upgrade 3 random cards.
Fresnel LensWhenever you add a card that gains Block to your Deck, Enchant it with Nimble 2.
Hand DrillWhenever you break an enemy’s Block, apply 2 Vulnerable.
History CourseAt the start of your turn, play a copy of your last played Attack or Skill.
Lost WispWhenever you play a Power, deal 8 damage to ALL enemies.
Maw BankWhenever you climb a floor, gain 12 Gold. No longer works when you spend any Gold at the shop.
Mr. StrugglesAt the start of your turn, deal damage equal to the turn number to ALL enemies.
Pollinous CoreEvery 4 turns, draw 2 additional cards.
Royal PoisonAt the start of each combat, lose 4 HP.
Swprd of JadeStart each combat with 3 Strength.
Sword of StoneTransforms into a powerful Relic after defeating 5 Elites.
Tea of DiscourtesyAt the start of the next combat, shuffle 2 Dazed into your Draw Pile.
The BootWhenever you would deal 4 or less unblocked attack damage, increase it to 5.
Wongo Customer Appreciation BadgeDoes nothing.
Wongo’s Mystery TicketReceive 3 random Relics after 5 combats.

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