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Slay the Spire 2 doesn’t have a traditional difficulty system in place, but the Ascension system and its levels will gradually raise the degree of challenge on your runs.

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Ascension levels, of which there are 20, apply separately for each character and apply certain modifiers to your runs. Let’s look at how the system works.

All Ascension level effects in Slay the Spire 2

The table below has complete information about all Ascension level modifiers.

Ascension LevelModifier
1More elite enemy spawns.
2Normal enemies have more attack and health.
3Stronger Elites that are harder to take down.
4Deadlier Bosses with greater strength and health.
5Get fewer heals after Boss battles.
6Start each run with damage.
7Find tougher normal enemies.
8Find tougher Elites.
9Find tougher Bosses.
10Start each run with a Cursed status.
11Start each run with one less slot for Potions.
12Less chances of finding upgraded cards.
13Encounter poor bosses.
14Max HP for your chosen character will be lower.
15Events will be of unfavorable nature.
16Shop items will be costlier.
17Normal enemies will have better abilities and moves.
18Elites will have better abilities and move.
19Bosses will have better abilities and move.
20Encounter two Bosses at the end of Act 3.

How to raise Ascension levels in Slay the Spire 2

To raise your Ascension levels, you have to complete a full run with a character. You gain one Ascension level for that character by doing so. If you manage to reach Ascension 20 for any character, you will have 19 modifiers available for them at the start of a run.

Hence, the more Ascensions you have, the tougher your runs will be. The ultimate challenge begins when you reach Ascension 20 with a character.

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