Yep, the box art for BioShock 2 sure does look similar in style and substance to the first ga--whoa. Now wait just a minute! What ... what is that? Look to the left of the Little Sister's head! What is that thing?
After asking around the office, here's what we were able to establish as possibilities:
What do you make of this, Destructoid community?
[Update: I do believe AngelsDontBurn has cracked the case.]