In a blog post, Edmund McMillen gave us the skinny on a game he's working on, The Binding of Isaac. He says it draws inspiration from The Legend of Zelda's dungeon structure, controls like Robotron: 2084 and Smash TV, and is coming to Steam this August for a price that "won't put much of a strain on your wallets."
Do I even need to go on? Isaac has a "randomly generated semi-RPG world filled with power-ups, items, and special abilities." The majority of the in-game items stack, "so as you progress your character will change into a monstrous powerhouse not only in stats and abilities but also in appearance."
This is going to be good.