Activision's released a new trailer for Prototype 2, detailing the history of Blackwatch. Don't know what Blackwatch is? Watch the video. It's detailed. They've done some bad things that have resulted in terrifying monsters. Jerks.
If you plan on playing Prototype 2 and missed out on the original, this video is a good primer. The game is out for PlayStation 3, Xbox 360, and PC next year, so you've still got time to catch up.