Descend into madness
If you saw the Darkest Dungeon Kickstarter, you are probably excited for the game. Seriously. Go watch the video. And then watch the above video of Holmes interviewing Lady Melissa at PAX about how your four characters' psychological health needs to be managed just as closely as their physical health.
It warns of the dangers of hedonism, too. Send a character to the brothel to rejuvenate one too many times and they might come down with the syphilis. Too many nights in the bar and you're on track towards alcoholism.
Sounds like my kind of adventure.