When you're lying in bed feeling sick, nothing beats a nice passve video game to raise your spirits. It's traditional for me to bust out Pokemon and carry on from one of my various savegames. It's simple, yet addictive, and time passes much more quickly. I was thinking about playing Littlebigplanet, but the psp version was pretty meh and the big TV for the PS3 started giving me a headache.
Any other games people recommend for when you feel like shit?