This almost qualifies as NVGR, but given Red Vs Blue's basis on Halo, I figure it counts. Kinda personal, tl;dr ahead, so if you're not into that, you can find the Back button easily enough.
Of all the things that have ever ended up tear-jerking experiences for me, Red vs Blue was the least expected inspiration for crying I've ever experienced. Sure, it's light-hearted joking and fun from the start, but by the end of the early Blood Gulch Chronicles season, darker themes are already beginning to creep in, and with the recent wrap of season 10, business got serious, and surprisingly deep.
Probably going to spoil a bit for those who haven't watched it all; head over to Rooster Teeth's site
if you want to get caught up.
LOOK WHO CAME: