Binding of Issac on Vita would be super awesome
Imagine being on the bus and pausing the game and getting back to the game later after getting to the bus terminal and playing until your next bus came. It's little things like this that make me love portable gaming.
This is also true if you want any future (post-Wrath) DLC. An optimized non-Flash version is being created because the Flash version can't handle more content. Wrath of the Lamb itself apparently caused headaches, where adding or fixing one thing would break another.
It's highly random. You'll have one game where nothing go right (like most objects being behind impassable pits, or lots of chests but no keys), and in the next the game will nearly hand you victory on a platter (powerful power-ups, just the items you need, etc). You'll get a run with shops but no money, and the next time you might get a ton of money with nothing worth spending it on.
That part may be poorly thought out (and largely seems to consist of "cool ideas" thrown into the game without much concern), but it is acceptable.
More problematic to me was the horrible performance (the game quickly slowed to a crawl on the first PC that I played it on long ago) and the annoying way that shots handled. Shots seemed designed to frustrate. The "arc" that "falling" tears took meant it wasn't immediately obvious where a shot was at any moment in the 2D map space. You could tell when the game was playing, but it took a moment of mental processing. On its own, even that wouldn't have been bad. But it was combined with the annoying idea of applying strafe inertia to shots. That inertia meant you could do a degree of "trick" shots to shoot around stuff, but it made it less obvious where any shot was going. Combining the two? Even with the game in motion, it took acclimatization to get the hang of just where you were shooting.
It's also surprisingly convenient, as I just watched Indie Game: The Movie this week.

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