The folks at EarthBound Central have been following Mother designer Shigesato Itoi's Twitter like they presumably always do, and apparently something is a brewing. The outlet translated two recent tweets:
"Since it's now okay to blurt this out, here goes: the "MOTHER republication" thing I mentioned briefly before is making progress," reads Itoi's first remark. "It's not "(MOTHER) 4", though! This has to do with making "MOTHER" playable. I can't give out any details just yet, but I do at least need to say that it isn't 4."
Vague, yes, but you know how we get. The translator says that Itoi is probably referring to the whole series here, not the original game, and that "playable" in this case has to do with the game(s) being out of print. Dare I plant the concept of a compilation in your mind? I'm going to think nothing of this, if at all possible, just to avoid potential disappointment. ...Okay, I give up.
Itoi Announces MOTHER Developments [EarthBound Central -- Thanks, Brian]