I've found that it's a rather fruitless endeavour to guess which games will get a sequel -- mainly because I'm usually wrong. If you'd asked me "Fraser, will there be a Zeno Clash II?" I would have confidently responded with "Outlook not so good." The original Zeno Clash was a wonderful, absurd, and utterly unique game, and thus not something that one would ever expect to see the like of again.
It's a good thing, then, that nobody asks me anything, because I would have looked rather silly. Zeno Clash II did happen, and I know this because I've been playing it. It's a grander, more ambitious title than its forebearer, and is filled with oodles of insanity and no small amount of pugilism. With the added scope comes a slew of problems, however, and I suspect that it won't be quite as fondly remembered as its predecessor.