Don't know about you, but I have a real soft spot for supernatural tales set during the frontier times in North America. The mixture of exploring a new world mixed with the superstitions and myths of the time is heady stuff. Sang-Froid - A Tale of Werewolves has just that sort of story with gameplay that combines third-person combat and tower-defense-esque strategy.
Greenlit by the Steam Community, Sang-Froid is currently in a closed beta for those who have pre-purchased the game. Despite having some interesting ideas, it's still quite rough round the edges.