[Disclosure: Jim Sterling, who provided voice work for Jazzpunk, was previously employed at Destructoid. As always, no relationships, personal or professional, were factored into the review.]
Describing Jazzpunk is pretty damn hard. It's billed as a "comedy adventure game," but it's so much more (and sometimes less) than that. It's packed full of references, oddball minigames, and voicework that will make you laugh more often than not.
For those reasons alone, it's not going to be for everyone. Unless you really like the idea of squirting a can of Cheez Whiz on Jim Sterling.