As we learned in "No fucking the robot," Fallout 4 will have romance options for the human percentage of its 12 companion characters.
Obsidian almost beat Bethesda to the punch in 2010. Fallout: New Vegas lead designer Josh Sawyer told PCGamer at PAX, "We actually had some ideas for characters that would… like in one story draft we had, Cass would get drunk with the protagonist and then would wake up with The King having married them at The King’s School of Impersonation.
"That seemed very Vegas, but we were also like, that’s kind of a complicated series of events, so we decided not to do it. But it’s also in the vein of the Fallout 2 more humorous romance, rather than in-depth and serious. It’ll be interesting to see how Bethesda approaches that in Fallout 4."