Everybody's Gone to the Rapture wouldn't end. I was lost in the middle of the 1984 English countryside having made my circuit trudging through several connected areas, yet suddenly I was back somewhere in the middle. Without the markers and paths I previously used to get there, I had lost my place in this world, and began walking even more aimlessly trying to find my way.
I was sent on this long journey -- yes, Rapture is slow-moving, even with the hidden sprint button -- because the last main story event refused to trigger. I thought there was else to do and I got lost trying to do it. Turns out I just needed to restart the game.