If a surgeon screwed up a delicate heart operation by messing around in real life, it would be both a tragedy and cause for a public outcry. In the realm of videogames, it's hilarious. Surgeon Simulator 2013 is a game all about life-or-death medical procedures -- using physics that fight you at every step.
Created for the Global Game Jam, this hastily constructed sim is bare-bones yet still utterly painful to watch. Wince in vicarious agony as a doctor reduces rib cages to jigsaw pieces while wailing in terror at his own murderous rampage. It's hilarious and agonizing.
Feel free to download it and try it for yourself. Grand Theft Auto's got nothing on this kind of malpractice.