Dutch studio Abbey Games is cooking up a title call Reus that's going in a different direction than Peter Molyneux's GODUS. Obviously there's plenty of room for both games (and many more!) to exist simultaneously, but if you are a fan of the genre who is not feeling what 22 Cans is working on, Reus might be more your speed.
Presented from a 2D perspective, this title revolves around giants (played by you) who can guide humankind through "terraforming, creation of life, control of weather and genetic manipulation" but cannot directly control people. In the studio's own words: "It's your responsibility to maintain a balance in which man is not overpowered by nature, and nature does not fall to man's greed."
In other words, you can lose influence over your citizens, and they can fight back. Sounds great, right? Even without really seeing what the moment-to-moment gameplay and presumed resource management will be like in Reus, I'm on board for this. It'll be hard to resist obliterating humans if and when they attack me, but some sacrifices must be made. Keep an eye out for this in Q2 2013.