As I mentioned I once tried to play F-Zero GX to distract my mind from the horrible hangover I was suffering with not so great results! It probably wasn't the best choice in hindsight but I did try Metroid Prime too and it didn't make me feel better either. But some games must be better than others when the fever is eating away at your mind and you're coughing up your lungs right?
If I try for example to play a RPG when I'm feeling like shit I just can't get any enjoyment out of it. I don't know if it's because being constantly reminded of your real and hurting body takes away much of the immersion or if it's just that thinking about stuff in general is a pain in the ass. I typically try to play something that's easy on the optic nerve and doesn't involve much planning, organizing or micro management. Preferably it's on a handheld, curled up under a blanket with a cup of tea, away from the prying eyes of the world. Something like Pokémon.
So what do you guys play when you feel like you've just been to Jonathan Holmes' Planetarium, or just feel generally broken?