Ok, ok, this may not be news to everyone, but it's news to me and I am a HOOGE guitar hero fan here so I am surprised that I haven't heard about this (it was actually announced at GDC 07...so yea...)
Guitar rising is coming out late this year and it is a PC based guitar hero evolution where you plug in an actual electric guitar and play along to one of 30 pre installed songs. What excites me is, if I know anything about PC games, and I do, then this will get hacked to buggary and we will instantly see all songs you've every wanted to learn to play on guitar appear on here for you to learn. Seriously, I have a feeling this is going to be really big - maybe not as big as Guitar Hero or Rock Band due to the fact you have to fork out for a real guitar, but either way - fucking laarge!
Check out the video and more details at the official webiste - http://www.guitarrising.com/