Voting will end Wednesday midnight, and then the work will commence!
So earlier I made
a post about my intent to make a Destructoid themed video game, with (hopefully) heavy input from the community.
So I asked you guys about what genre the game should be, and well it's been really close between Beat 'Em Up and Tower Defense and not that many people have voted.
So I ask you, what you think it should be?
Beat 'em up or Tower Defense?
In the case of beat 'em up I'd probably do something along these lines:
Arrow Keys to move.
Hold left shift to run.
S, D, F, W, E and R will be buttons for six slots, different moves which you can [i]find/earn/unlock would go in these slots.
C would bring up your inventory, (items for clothing/weapons/etc.)
V would bring up your skill menu, and allow you to switch the moves in the slots.
In game currency would revolve around comments.
Sample moves/items being:
Drink: Restores health, various levels, something like: pint, pitcher and keg
Flame: OMG INTERNET FIGHT
Banhammer
LAZAR: FIRIN MAH LAZAR
Ray Gun: Pew pew pew
Bombs: bomberman
Spam blogging: Rapid fire blog pages that immediately combust due to flaming
Rick Roll: Rick Atsley, you roll him into people
Double Post: % Chance to do a double attack
Repost: Increase in comment count for kill
Also, cocks: % Chance a rooster will come help you fight for awhile after every attack.
As far as what I'd do for Tower Defense, well I'm not sure yet, it wasn't really winning when I started brainstorming...
Sample enemies for either game would be along the lines of: Wiisucks, Noob posters ("GOD TOL ME 2 POST1!" credit: Brecksher), Trolls, DMCA problems, cursed PS3s, Red Rings ... 
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BEAT EM UP.
However, your control scheme for a beat 'em up seems...overly complex. Generally they have something along the lines of a jump button, an attack button, and sometimes a special attack button.
Perhaps if you had the special skills, but only had one selected at a time? Then you could do something like the following:
Move: Arrow Keys , run with double-tap
Jump: A
Basic Attack: S
Special Attack (One of your 6 skills mentioned): D
Select Previous Special: Q
Select Next Special: E
Pause/Skills/Inventory: Space
Special skills could be limited by a special meter that recharges slowly over time or something.
And always remember the golden rule of beat 'em ups.
Punch-punch-punch-UPPERCUT!
Also, the cursed PS3 has been rather tame. I have an SNES nearby that keeps it in line.