There are no spoilers, unless a few that reveal nothing count. I was beating Mass Effect 1, because it didn't want to be a noob who didn't import. Anyways, as I'm going in the Mako to one of the final sections of the game, I hear "IT'S A TRAP!" from Wrex.
That is the most I've laughed at a video game in recent memory. Either BioWare put that in on purpose, or by chance it ends up that the weird looking lizard thing says that, but I don't care, because that was amazing, and made my day.