With Gore Verbinski stepping down as director for the sadly inevitable BioShock movie (though hanging on as producer), there's an opening for a new man to steer the project forward. Universal Studios wants that man to be Juan Carlos Fresnadillo. He's the chap who made 28 Weeks Later, as if our headline didn't give enough of a clue.
Fresnadillo is in talks right now over the project, but final approval will come from Take-Two, which has final approval on any directors. Of course, the film could do much worse than have Fresnadillo on board, so I think the game publisher should say yes unless it wants something like Michael Bay or, worse, Uwe Boll to jump on the script. Fresnadillo's producing partner, Enrique Lopez Lavigne, may also come on board as a producer.
The Infected from 28 Weeks Later kind of act like Splicers, being that they're both diseased freaks that rush headlong at people and don't make any sense why they try and speak. Should be an easy job for this particular director, really.