In BioShock Infinite players are presented with a world, or rather a floating city, in conflict. Both ideological and physical. The conflict is between the dominant right-wing nationalists, the Founders, and a coalition of populist groups who feel disenfranchised, the Vox Populi. On the surface it's not completely dissimilar to what's happening in the US with the rise of the Tea Party and Occupy Wall Street. Ken Levine spoke with The Washington Post to discuss how real life is reflected in video games.
I think that because the original BioShock took place after the conflict in Rapture and the game was dealing with more abstract ideas like moral absolutism as well as an ideology that has fallen out of favor, Objectivism, it was more distant and less personal. But BioShock Infinite takes place in the middle of a conflict. One between two recognizable groups that hold a mirror to many groups throughout history. So it's easier to draw comparisons. Of course, the side effect of that is that there are plenty of people in those groups who take it personally.
Personally, I'm looking forward to people criticizing and debating the perceived message of BioShock Infinite when it comes out. It will give me an excuse to be a boring git and talk about politics after I've just fought a giant metal bird and opened a portal to another time. Best of both worlds. The full interview is here. Don't worry, it's not all politics and history, videogames do get mentioned.
The tea party, Occupy Wall Street and 'BioShock Infinite...' [The Washington Post]