Edmund McMillen's latest personal project, The Binding of Isaac, looks as weird as everything else the man has ever done in videogames. The latest trailer appears to place its focus on the variety of enemies Isaac will encounter as he flees his mother. It was made by James ID (who also made the totally radical 90's Super Meat Boy trailer) and is a little unsettling for some reason I can't put my finger on. Maybe it's the bald, naked, screaming guy.
You'll be able to pick up The Binding of Isaac next month on Steam (PC and Mac) for the saintly sum of $5.
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destructoid's previous coverage: The Binding of Isaac