We've gotten many hints that Binding of Isaac Rebirth will be a very large game, but a new blog update shines a little more light on what goes into that equation. While the original game and the expansion had 198 items, Rebirth will have over 450, as well as 50 new enemies and 15 new bosses -- as well as "double trouble" boss fights were you have to battle two at once.
The new randomly generated dungeons are also highlighted, and while the old version had 150 rooms per chapter, Rebirth will have 500 per. That's pretty crazy, and sounds like a completely different game -- I can't wait to try it out.
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destructoid's previous coverage: The Binding of Isaac: Rebirth