The Binding of Isaac: Rebirth is one of my most anticipated games of 2013. The new sprite-based graphics and the promise of additional content is giving me the vapors. The original Isaac looks great too, but this new "16-bit" style makes the game feel new again, while simultaneously tricking my subconscious into the idea that Isaac has been around since the '90s, and that I'm just discovering it now for the first time.
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destructoid's previous coverage: The Binding of Isaac: Rebirth